7/19/2023 0 Comments A very slow discovery challenge![]() Jana and Hsieh coined the term “transcriptional-translational conflict” to describe the emergency brake they discovered. At the same time, the mutated cells ramp down a molecule needed to turn these genes’ messenger RNAs into the cancer-causing proteins that enable unrestrained tumor growth and survival. Sujata Jana, PhD, a postdoctoral fellow in Hsieh’s lab, found that mutation of a key tumor-suppressing gene, called ARID1A, in bladder cells ramps up a suite of cancer-causing genes. “We’ve also showed that (in preclinical models of bladder cancer) we can reinstall this emergency brake.” “We think what we have defined is a new tumor-suppressive mechanism,” said Andrew Hsieh, MD, the Fred Hutch physician-scientist who studies bladder and prostate cancers and treats patients with these diseases. In a study published April 20 in Cancer Cell, the team also manipulated the brake to halt the growth of human bladder tumors in mice, suggesting that the newly discovered molecular fail-safe could be a target for future bladder cancer therapies. Now, Fred Hutchinson Cancer Center scientists have discovered a completely new - and counterintuitive - “emergency brake” that bladder cells use to stave off tumors even when cancer-promoting genes are turned on. Understanding natural anti-tumor processes could help researchers develop better approaches to treat or prevent cancer. “Social proof is becoming a decision maker and breaker, as younger demographics look to their peers for transparent endorsements,” Coveo said.Over the decades, scientists have revealed many strategies that keep normal cells from becoming cancerous. Reviews and recommendations from other shoppers are also valuable. Sites can use artificial intelligence to provide insights about how many others have purchased a product that day, or even how many currently have it in their carts. Such data, along with information about how other consumers are transacting, can encourage shoppers to buy. “A person taking time to shop on your site-finding items and deliberating whether they are the right ones-needs to know if there are just two items remaining,” Coveo said. A consumer browsing a brand’s e-commerce site should have access to critical inventory insights, such as whether product is running low. Mindfully using consumer data is key to “boosting trust and creating a motivator to buy,” Coveo added. Coveo said 22 percent of respondents complain that they don’t have the option to see if stock is available in local stores. This means retailers must communicate product availability information, which requires implementing these cross-channel backend inventory data systems. Omnichannel remains top of mind, with shoppers showing “a strong preference for researching products before purchasing.” The majority (79 percent) do so online and using social media, and 37 percent look at products online before purchasing in store. Improving the online experience can also affect on a brand’s physical retail business, according to Coveo. They’re bothered by problems with product discovery (46 percent), and no options to filter their search (11 percent). Gen Z consumers are the harshest critics, with 96 percent reporting poor experiences. However, 92 percent said they often encounter issues online, from poor site performance or slow loading time (33 percent) to trouble finding what they’re looking for (32 percent), missing product information (27 percent), disorganized navigation (26 percent), lack of mobile-friendly site design (25 percent) and irrelevant recommendations (24 percent). ![]() ![]() Ninety-three percent of respondents said they have high expectations of the online shopping experience, and expect it to be superior to purchasing in stores. “If the shoppers pony up, retailers need to as well.” It also noted that in-session personalization using AI can provide targeted product recommendations even if shoppers only log in at checkout-or not at all. “In other words, retailers need to make it worth their while to share that data,” Coveo said. Over half (52 percent) said they’re willing to share their data in exchange for better deals and offers. The right incentives still work, however. That makes personalization, like offering targeted promotions and product discovery opportunities, more difficult. “This means the majority of a shopper’s buying journey is anonymous,” Coveo said. Nearly half of respondents (48 percent) said they’ve fully abandoned their digital carts when prompted to create an account. Seventy-two percent said they only log into a site at checkout, while 32 percent opt for guest check out. ![]() Another 68 percent are concerned about the way online retailers will use their daya. Notably, most digital shoppers (57 percent) are only vaguely aware of how much data they share when buying online, from Gen X to Gen Z.
0 Comments
Leave a Reply. |